Provided is a tissue retrieval bag. The bag is made primarily of a first material, the bag having a region defining an opening a pleated fold intersecting the opening. The bag has at least one porthole on at least one side of the bag. The at least one porthole is covered by a second material, the second material being different from the first material. The bag also includes a first hem circumferentially formed around the opening, the first hem forming insertion points adapted to receive a first draw string.
