The Third Institute of Oceanography, State Oceanic Administration, People's Republic of China; Ltd.;Xiamen Zhaoyang Biological Engineering Co.;Xiamen Zhaoyang Biological Engineering Co., Ltd.
A stable freeze-dried preparation of tetrodotoxin and the producing method thereof. The feeze-dried preparation has tetrodotoxin as the main active ingredient, and comprises solubilizer, excipient and stabilizer. The said solubilizer is citric acid. The excipient is sodium, mannitol or their composite. The stabilizer is dextran, trehalose or their composite. The ratio of tetrodotoxin, excipient and stabilizer is 1 : 150-3000 : 50-500 or 50-6000. Preferably, the praparation comprises lidocaine hydrochloride as function modulator. The preparation of the prensent invention can be used for blocking the dependence/withdrawal syndrome of drugs such as opiums and cannabis.
