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НОВЫЕ ДИГИДРО-ОКСАЗОЛОБЕНЗОДИАЗЕПИНОВЫЕ СОЕДИНЕНИЯ, СПОСОБ ИХ ПОЛУЧЕНИЯ И СОДЕРЖАЩИЕ ИХ ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ
专利权人:
LES LABORATOIRES SERVIER;EGIS GYOYSZERGYAR NYRT
发明人:
LING ISHTVAN,BARKOTSI JOZHEF,ANTONI FERENTS,GACHALIJ ISHTVAN,LEVAI D'ERD',SPEDDING MAJKL,KHARSHING LASLO,ЛИНГ Иштван,БАРКОЦИ Йожеф,АНТОНИ Ференц,ГАЧАЛИЙ Иштван,LEVAI DERD,ЛЕВАИ Дьёрдь,СПЕДДИНГ Майкл,ХАРШИНГ Ласло
申请号:
RU2013144824
公开号:
RU2572556C2
申请日:
2012.03.07
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
FIELD: medicine, pharmaceutics.SUBSTANCE: invention relates to compounds of formula(I) or their pharmaceutically acceptable acid addition salts, where Rrepresents hydrogen atom or linear or branched (C-C)alkyl group; Rrepresents linear or branched (C-C)alkyl group; Rrepresents aryl or heteroaryl group; where aryl group represents naphthyl group, optionally substituted with one or several identical or different groups, selected from halogen atoms; linear or branched (C-C)alkyl group, which is non-substituted or is substituted with one or several halogen atoms; linear or branched (C-C)alkoxygroup; cyanogroup; or aminogroup, which is non-substituted or is substituted with one or two linear or branched (C-C)alkyl groups; and heteroaryl group represents bicyclic or tricyclic group, in which at least one of rings is aromatic, which contains from 1 to 3, identical or different, heteroatoms, selected from nitrogen, oxygen and sulphur, optionally substituted with one or several identical or different groups, selected from halogen atoms; linear or branched (C-C)alkyl group, which is non-substituted or is substituted with one or several halogen atoms; linear or branched (C-C)alkoxygroup; cyanogroup; or aminogroup, which is non-substituted or is substituted with one or two linear or branched (C-C)alkyl groups. Invention also relates to method of obtaining formula (I) compounds, pharmaceutical composition, containing formula (I) compound as active ingredient, and application of formula (I) compounds for preparation of medications.EFFECT: formula (I) compounds, possessing selective activity with respect to ?subunit of GABAreceptor.16 cl, 5 dwg, 56 exИзобретение относится к соединениям формулы (I) или их фармацевтически приемлемым кислотно-аддитивным солям, где Rпредставляет собой атом водорода или линейную или разветвленную (C-С)алкильную группу; Rпредставляет собой линейную или разветвленную (С-С)алкильную группу; Rпредставляет собой арильную или гетероарильную группу; где ариль
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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