The present invention provides compositions and methods relating to or derived from antigen binding proteins capable of inducing B-Klotho, and or FGF21-like mediated signaling. In embodiments, the antigen binding proteins specifically bind to a complex comprising β-Klotho and at least one of (i) FGFR1c, (ii) FGFR2c and (iii) FGFR3c. In some embodiments the antigen binding proteins induce FGF21-like signaling. In some embodiments, an antigen binding protein is a fully human, humanized, or chimeric antibodies, binding fragments and derivatives of such antibodies, and polypeptides that specifically bind to a complex comprising β-Klotho and at least one of (i) FGFR1c, (ii) FGFR2c and (iii) FGFR3c. Other embodiments provide nucleic acids encoding such antigen binding proteins, and fragments and derivatives thereof, and polypeptides, cells comprising such polynucleotides, methods of making such antigen binding proteins, and fragments and derivatives thereof, and polypeptides, and methods of using such antigen binding proteins, fragments and derivatives thereof, and polypeptides, including methods of treating or diagnosing subjects suffering from type 2 diabetes, obesity, NASH, metabolic syndrome and related disorders or conditions.本發明提供與能夠誘發B-Klotho及或FGF21樣介導之信號傳導之抗原結合蛋白相關或自其衍生之組合物及方法。在實施例中，該等抗原結合蛋白特異性結合至包含β-Klotho及(i)FGFR1c、(ii)FGFR2c及(iii)FGFR3c中之至少一者的複合物。在一些實施例中，該等抗原結合蛋白誘發FGF21樣信號傳導。在一些實施例中，抗原結合蛋白係特異性結合至包含β-Klotho及(i)FGFR1c、(ii)FGFR2c及(iii)FGFR3c中之至少一者之複合物的完全人類、人類化或嵌合抗體、該等抗體之結合片段及衍生物及多肽。其他實施例提供編碼該等抗原結合蛋白、及其片段及衍生物、及多肽之核酸；包含該等聚核苷酸之細胞；製造該等抗原結合蛋白及其片段及衍生物及多肽的方法；及使用該等抗原結合蛋白、其片段及衍生物及多肽的方法，包括治療或診斷患有2型糖尿病、肥胖症、NASH、代謝症候群及相關病症或病況之個體的方法。
