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K-RAS MODULATORS
专利权人:
LEIDOS BIOMEDICAL RESEARCH, INC.;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人:
MCCORMICK, Frank,RENSLO, Adam,TURNER, David,MACIAG, Anna,DYBA, Marcin,VO, Elizabeth,SAAVEDRA, Joseph,KUMARI, Vandana
申请号:
SG11201909570P
公开号:
SG11201909570PA
申请日:
2018.04.20
申请国别(地区):
SG
年份:
2019
代理人:
摘要:
KrasbH 5C (GppNHp dose response 100 200 300 400 500 Concentration (uM) (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 25 October 2018 (25.10.2018) WIPO I PCT Iiiimmomiolollmonolomomnioomlloonomoun (10) International Publication Number WO 2018/195439 A2 (51) International Patent Classification: CO7D 405/14 (2006.01) CO7D 241/12 A61K 31/4192 (2006.01) CO7C 233/76 (2006.01) (2006.01) C07D 231/56 (2006.01) CO7D 207/40 (2006.01) CO7D 403/06 (2006.01) CO7D 213/40 (2006.01) CO7D 237/08 (2006.01) CO7D 303/36 (2006.01) CO7D 403/14 (2006.01) CO7D 305/06 (2006.01) CO7D 239/26 (2006.01) CO7D 307/28 (2006.01) CO7D 405/12 (2006.01) A61P 35/00 (2006.01) (21) International Application Number: PCT/US2018/028593 (22) International Filing Date: 20 April 2018 (20.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/487,756 20 April 2017 (20.04.2017) US (71) Applicants: THE REGENTS OF THE UNIVERSI- TY OF CALIFORNIA [US/US]; 1111 Franklin Street, 12th Floor, Oakland, CA 94607-5200 (US). LEIDOS BIOMEDICAL RESEARCH, INC. [US/US]; P.O. Box B, 1050 Boyles Street, Frederick, MD 21702 (US). (72) Inventors: MCCORMICK, Frank; 5 Bernice St., San Francisco, CA 94103 (US). RENSLO, Adam; 5359 Shafter Avenue, Oakland, CA 94618 (US). TURNER, David; 501 Prospect Blvd., Apt. 24C, Frederick, MD 21701 (US). MACIAG, Anna, E.; 9214 Charterhouse Rd., Frederick, MD 21704 (US). DYBA, Marcin; 1930 Moran Drive, Frederick, MD 21702-6443 (US). VO, Elizabeth, D.; 391 Valencia St., Apt. 302, San Francisco, CA 94103 (US). SAAVEDRA, Joseph; 7189 Browns Ln, Thurmont, MD 21788 (US). KUMARI, Vandana; 9159 Bealls Farm Road, Frederick, MD 21704 (US). (74) Agent: TERRANOVA, Zachary, L. et al.; Mintz Levin Cohn Ferris Glovsky and Popeo, P.C., One Financial Cen- ter, Boston, MA 02111 (US). (81) Designated States (unless otherwise indicated, for e
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