THOMAS CHITTENDEN,LINGYUN RUI,DANIEL TAVARES,YELENA KOVTUN
申请号：
ARP160101974
公开号：
AR105194A1
申请日:
2016.06.29
申请国别(地区):
AR
年份:
2017
代理人:
摘要：
1. Claim 1: the binding of an antibody or part of it with the antigen, which: (a) the 101-346 entry of il3-ra / CD123 human antigen is added and (b) the diffusion dependent on IL3 is inhibited to make it an antibody positive TF-1 cell. Requirement42: antibodies in any claims 1-3 and 5-20 or binding parts with Oriental antigens, including: (a) a variable region in immunoglobulin heavy chain, including a CDR1 containing amino acid sequence determined by SEQ ID 5.CDR2 is an amino acid sequence determined by SEQ ID No. 6, No. 7, No. 8, No. 9 or No. 10 and an amino acid sequence determined by CDR3, SEQ ID No. 11 and (b) immunoglobulin light chain transformation region, including a CDR1 containing an amino acid sequence determined by SEQ ID No. 19 or No. 20, CDR2 containing amino acid sequence, determined by SEQ ID No. 21,And a CDR3 containing an amino acid sequence, determined by SEQ ID 22. Claim 55: a polypeptide comprising VH and VL sequences in any claims 1-54. Claim 57: a cell that produces an antibody or binding part of an antigen from any claim 1-54 or polypeptide 55 or 56 of the claim. Claim 58: a method for the production of antibody in any one of claims 1-54 or the part of the claim combined with the antigen or polypeptide 55 or 56 in the claim, including: (a) culture of cells in claim 57 and (b) isolation of such antibodyThe binding part of polypeptide antigen of this cultured cell Claim 60: an immunococci containing formula (1), wherein CBA is an antibody or antigen binding fragment in any one of the claims of 23-26, or a polypeptide of 55 or 56 in this claim, which is connected with cyl1 by a lysine residue；WL is an integer from 1 to 20, and CYL 1 is represented by formula (2) or (3),or a pharmaceutically acceptable salt thereof, in which: the double line ⁻ ⁻ ⁻ ⁻ ⁻ between N and C represents a single bond or a double bond, provided that when it is a double bond X it is absent and Y is -H or a C₁₋₄ alkyl and, when it is a single bond, X is -H or an amine prote
