The present invention relates to an injectable pre-formulation comprising a low viscosity mixture of: a) at least one neutral diacyl lipid and/or at least one tocopherol； b) at least one phospholipid； c) at least one oxygen containing organic solvent； d) at least one 5HT3antagonist； wherein the pre-formulation forms, or is capable of forming, at least one liquid crystalline phase structure upon contact with an aqueous fluid. Such compositions may additionally comprise polar solvents and/or further active agents such as opioid agonists and/or antagonists. Methods of treatment, particularly for management of nausea and vomiting such as for post-operative nausea and vomiting and/or therapy induced nausea and vomiting are provided, as well as corresponding uses of the compositions. Administration devices comprising the formulations and kits comprising the devices are also provided.本發明係關於可注射預調配物，其包含以下各項之低黏度混合物： a) 至少一種中性二醯基脂質及/或至少一種生育酚； b) 至少一種磷脂； c) 至少一種含氧有機溶劑； d) 至少一種5HT3拮抗劑； 其中該預調配物在與水性流體接觸時形成或能形成至少一種液晶相結構。該等組合物可另外包含極性溶劑及/或其他活性劑(例如類鴉片(opioid)激動劑及/或拮抗劑)。本文提供具體而言用於管控噁心及嘔吐(例如手術後噁心及嘔吐及/或療法誘導之噁心及嘔吐)之治療方法以及該等組合物之相應用途。本文亦提供包含該等調配物之投與裝置及包含該等裝置之套組。
