包含有光學活性托伐普坦（ＴＯＬＶＡＰＴＡＮ）之可注射的補給配方，及其製造方法农业专利-农业专业知识服务系统

发明人:: KANEKO, DAIKI,金子大树,金子大樹,MATSUDA, TAKAKUNI,松田贵邦,松田貴邦,MIYATA, KENICHI,宫田宪一,宮田憲一,SUZUKI, KAI,铃木海,鈴木海,FUJIKI, HIROYUKI,藤木浩之,KINOSHITA, SHIZUO,木下静男,木下靜男,OHMOTO, KOJI,大本浩嗣,AIHARA, MIKI,相原美纪,相原美紀

摘要：: This invention provides an injectable formulation to be administered intramuscularly or subcutaneously that is used for the prevention or treatment of polycystic kidney disease, and that can maintain a therapeutically effective blood concentration of tolvaptan for a long period of time； and a process for producing the same. More specifically, this invention relates to an injectable depot formulation comprising (1) a particle containing optically active tolvaptan as an active ingredient and (2) a pharmaceutically acceptable carrier for injection, and a process for producing the same.本發明係提供一種以肌肉或皮下給藥之可注射的配方，其用於多囊性腎病之預防或治療，及其可長時間維持托伐普坦(tolvaptan)之治療有效之血中濃度；以及其製造方法。更具體地，本發明係有關一種包含(1)作為活性成分之含有光學活性托伐普坦之顆粒，及(2)用於注射之藥學上可接受載劑之可注射的補給配方，以及其製造方法。