John A. Lewicki;Sanjeev Satyal;Timothy Hoey;Austin Gurney;Wan-ching Yen
发明人:
John A. Lewicki,Austin Gurney,Timothy Hoey,Wan-ching Yen,Sanjeev Satyal
申请号：
US13472301
公开号：
US08404237B2
申请日:
2012.05.15
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis, characterization, prognosis and treatment of cancer and specifically targeting cancer stem cells. The present invention provides an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human NOTCH receptor and inhibits growth of tumor cells. The present invention further provides a method of treating cancer, the method comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human NOTCH receptor protein and inhibits growth of tumor cells.
