Richard F. Jones;Marie P. Piechocki;Wei-Zen Wei;Gen Sheng Wu
发明人:
Wei-Zen Wei,Gen Sheng Wu,Marie P. Piechocki,Richard F. Jones
申请号：
US14155592
公开号：
US20140205538A1
申请日:
2014.01.15
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The invention provides therapeutics and methods to induce a mammalian host, including a human, to produce antibodies, which agonize death receptors and cause the apoptotic death of target cells within the host's body. The therapeutics are vaccine compositions, including genetic vaccines encoding death receptor antigens of the tumor necrosis factor receptor family. Also provided are means and methods for overcoming host immunological tolerance to death receptors. The vaccines are useful against cancer cells and other death receptor bearing target cells within the host, and can be used in both therapeutic and prophylactic settings. The vaccines are also useful for diagnostic testing of the immunocompetence of a host.
