PROBLEM TO BE SOLVED: To provide a pharmaceutical composition useful for the treatment of disease caused by target tissues, to provide the active ingredient thereof, and to provide a screening method and a production method of the pharmaceutical composition and the active ingredient.SOLUTION: The invention provides an antigen-binding molecule comprising an antigen binding domain which changes binding activity against an antigen depending on the concentration of a compound specific to target tissues. The antigen-binding molecule is comprised in an Fc region comprised in a constant region of a specific sequence, and comprises an FcγR binding modified Fc region with higher binding activity to an Fcγ receptor than that to the Fcγ receptor of the Fc region of a natural human IgG. Using the antigen-binding molecule enables a target tissue specific therapy of various diseases caused by target tissues.SELECTED DRAWING: NoneCOPYRIGHT: (C)2020,JPO&INPIT【課題】標的組織に起因する疾患の治療に有用な医薬組成物、その有効成分、前記医薬組成物並びに前記有効成分のスクリーニング方法、及び、製造方法の提供。【解決手段】標的組織特異的な化合物の濃度に依存して抗原に対する結合活性が変化する抗原結合ドメインを含む抗原結合分子。特定配列の定常領域に含まれるＦｃ領域に含まれるもので、天然型ヒトＩｇＧのＦｃ領域のＦｃγレセプターに結合性よりも、Ｆｃγレセプターに対する結合活性の高いＦｃγＲ結合改変Ｆｃ領域を含む抗原結合分子。前記抗原結合分子を用いることにより、標的組織に起因する各種疾患を標的組織特異的に治療することが可能となる。【選択図】なし
