The present disclosure provides compounds with a hydrophilic self-immolative linker, which is cleavable under appropriate conditions and incorporates a hydrophilic group to provide better solubility of the compound. The compounds of the present disclosure comprise a drug moiety, a targeting moiety capable of targeting a selected cell population, and a linker which contains an acyl unit, an optional spacer unit for providing distance between the drug moiety and the targeting moiety, a peptide linker which can be cleavable under appropriate conditions, a hydrophilic self-immolative linker, and an optional second self-immolative spacer or cyclization self-elimination linker.本揭示案提供具有親水性自消耗連接子的化合物，該連接子在適宜條件下可被剪切及結合親水性基團以提供化合物之更好的可溶性。本揭示案之化合物包含藥物部分、能夠靶向選定的細胞群體之靶向部分，及連接子，該連接子含有醯基單元、用於在藥物部分與靶向部分之間提供距離的可選間隔基單元、可在適宜條件下可被剪切之胜肽連接子、親水性自消耗連接子及可選第二自消耗間隔基或環化自消除連接子。
