The present invention relates to compositions comprising an IL-12 protein having a first and second subunit, an EDB-binding domain, and a linker between the IL-12 protein and the EDB-binding domain.本發明係關於組合物,其包含具有第一及第二亞單元的IL-12蛋白、EDB結合域,及介於IL-12蛋白與EDB結合域之間的連接子。