JACKY, BIRGITTE PS,BRIDEAU-ANDERSEN, AMY,YOU, HUI,FRAIL, DONALD E.,BRIN, MITCHELL F.
申请号：
CA3086185
公开号：
CA3086185A1
申请日:
2018.12.20
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
A polypeptide having an amino acid sequence corresponding to a binding domain of a botulinum toxin is described. The polypeptide modulates expression of genes involved in, for example, collagen production and extra cellular matrix organization, and finds use, therefore in treating or reducing the occurrence of a disease such as a disease of the ECM, a connective or epithelial tissue disease, an endothelial disease or a fibrotic disease, e.g., a fibrotic disease of the ECM, connective tissue, or endothelium. Nucleic acids encoding the polypeptide, as well as vectors, host cells, and systems comprising the nucleic acids, are further described.
