WOLFGANG WIENEN,MARC GRUNDL,THORSTEN OOST,ALEXANDER PAUTSCH,STEFAN PETERS,DORIS RIETHER
申请号：
ARP120103441
公开号：
AR087913A1
申请日:
2012.09.18
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
N - [1-cyano-2 - (phenyl) ethyl] - 2-azabicyclo [2, 2, 1] heptan-3-carbox of the form (1) and its use as c-catepsian inhibitors, agents containing these agents, and methods for treating and / or preventing respiratory diseases. Claim 1: compound with equation (1), n is 0, 1, 2, 3 or 4； R 1 is c83218c83226；Halogen, HoweC₁₋₆-O- alkyl,H₂N-,C₁₋₆-HN-alkyl,(Alquil C) N-alquil C -C (O) HN-R2 is h, halogen, or selected from the group, including: Lease No. c8332131 / 832626；C₂₋₆ alkenyl,1. C 83228331 asphalt；C₃₋₆ cycloalkyl or C₃₋₆ cycloalkenyl each optionally substituted independently of one another,con uno dos tres o cuatro Ra monocyclic C₅₋₇ heterocyclyl, wherein one or two carbon atoms are replaced by heteroatoms selected from -S-,-S (O) --S (O) --O-o-n-and ring are completely and partially saturated, and can optionally replace each other,con uno dos tres o cuatro Rbicyclic C₈₋₁₀ heterocyclyl, wherein one, two, three, or four carbon atoms are replaced by heteroatoms selected from -S-,-S (O) --S (O) --O-o-n-and ring are completely and partially saturated, and can optionally replace each other,con uno dos tres o cuatro Ra. C83325583； 8320；One, two, three or four of the carbon atoms are replaced by the selected heteromorphic atoms,-S (O) --S (O) --O-o-n-and rings are aromatic, and alternative alternatives are independent of each other,con uno dos tres o cuatro RArilo, optional stand-alone replacement,con uno dos tres o cuatro RThat's what it means, that's what it means.Option 2: independent replacement,con uno dos tres o cuatro RR2, 1 is halogen, lease land c832131；cycloalkyl C₃₋₆,I...this is it.C₁₋₆-O- alkyl,alquil C - (O) C-alquil C -O (O) C-C₁₋₆-HN-alkyl,(Alquil C) N-1. C83218331 asphalt-s -,alquil C - (O) S-alquil C - (O) S-alquil C - (O) SO-(Alquil C) N (O) C-alquil C -HN (O) C-alquil C - (O) CHN-1. C833218331c8326c (o) Baibai reservoir (c8332126n)；C₃₋₆-HN- cycloalkyl,cicloalquil C - (O) C-Ho - lessor c83218c31832626,MeO-alkyl C₁₋₆,NC...(C₁₋₆ alkyl) ₂N (O) ₂S-,alquil
