NOVEL SELENOFLAVONE COMPOUND AS AGENT FOR TREATMENT OF OBESITY农业专利-农业学术服务平台

专利权人:: 연세대학교 산학협력단; YONSEI UNIVERSITY;INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY;INDUSTRY-ACADEMIC COOPERATION FOUNDATION

发明人:: JEONG, JIN HYUNKR,정진현,YANG, WOO RAMKR,양우람,CHOI, YONG SUNGKR,최용성,LEE, YUN HEEKR,이윤희,KWON, HYUN JUNGKR,권현정,JEONG, JIN HYUN,YANG, WOO RAM,CHOI, YONG SUNG,LEE, YUN HEE,KWON, HYUN JUNG

摘要：: The present invention relates to a process for producing a novel selenoflavone compound and a pharmaceutical composition for preventing or treating obesity comprising the selenoflavone compound. In the present invention, selenoflavone, especially PMSF, which has never been synthesized due to synthetic difficulties can be synthesized through palladium-catalyzed direct C-H arylation. Since the synthesized selenoflavone has an improving effect related to activation of brown adipose tissue (BAT), the selenoflavone can be used in the composition for prevention and treatment of obesity.COPYRIGHT KIPO 2018본 발명은 신규한 셀레노플라본 화합물의 제조 방법 및 상기 셀레노플라본 화합물을 포함하는 비만 예방 또는 치료용 약학 조성물에 관한 것이다.본 발명에서는 팔라듐-촉매를 사용하여 직접적 C-H 아릴화(palladium-catalyzed direct C-H arylation)를 통해 합성적인 어려움으로 인해 합성된 적이 없었던 셀레노플라본, 특히 PMSF을 합성할 수 있다. 상기 합성된 셀레노플라본은 BAT (brown adipose tissue)의 활성화와 관련된 개선 효과를 가지므로, 상기 셀레노플라본은 비만의 예방 및 치료를 위한 조성물에 사용될 수 있다.