Systems and methods for detecting extubation of an endotracheal tube (ETT) are described. Extubation of the ETT can be identified by comparing to a threshold, a difference between a determined first volume of breathing gas during a first inspiratory period to a determined second volume of breathing gas during a second inspiratory period. If the difference exceeds the threshold, an alarm can be activated indicating extubation. Extubation detection may also be based on a difference between inspiratory pressures during separate inspiratory periods. Partial extubation and full extubation may also be discerned. Further, extubation of an ETT may be detected without the use of an exhalation flow sensor.
