The present invention relates to methods of migraine prophylaxis using anti-CGRP receptor antibodies or binding fragments. In particular, methods for preventing or reducing the occurrence of migraine headache in a patient in need thereof comprising administering to the patient an anti-CGRP receptor or binding fragment according to specific dosage regimens are disclosed. Pharmaceutical compositions and administration devices comprising anti-CGRP receptor antibodies or binding fragments for use in the methods are also described.本發明係關於使用抗CGRP受體抗體或結合片段預防偏頭痛之方法。詳言之,本發明揭示用於預防或減少有需要之患者偏頭痛之發生的方法,其包含根據特定劑量方案,向該患者投與抗CGRP受體或結合片段。本發明亦描述包含用於該等方法中之抗CGRP受體抗體或結合片段的醫藥組合物及投藥裝置。