Brian John Smith;John Gerbrandt Tasman Menting;Michael Colin Lawrence;Colin Wesley Ward
发明人:
Michael Colin Lawrence,Brian John Smith,John Gerbrandt Tasman Menting,Colin Wesley Ward
申请号：
US13265879
公开号：
US20120122771A1
申请日:
2010.03.09
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates generally to structural studies of the insulin binding site of the insulin receptor (IR) and the insulin-like growth factor 1 receptor (IGF-1R). More particularly, the present invention relates to the crystal structure of the low affinity insulin binding site of the IR ectodomain comprising the C-terminal region of the IR α-chain, as well as the corresponding region of IGF-1R, and to methods of using the crystal and related structural information to screen for and design compounds that interact with or modulate the function of IR and/or IGF-1R.
