DR RENUKA METGUD,DR RUCHI BHATIA,DR SHWETA SHIVAYOGI HUGAR,U R BOLMAL
申请号：
IN201741044061
公开号：
IN201741044061A
申请日:
2017.12.08
申请国别(地区):
IN
年份:
2017
代理人:
摘要：
Abstract: The present invention relates to the development of effective composition for local drug delivery system as an adjunct to scaling and root planing for treatment of chronic periodontitis.. It specifically relates to the development of effective composition with green tea extracts in the form of chips for local drug delivery system as an adjunct to scaling and root planing for treatment of chronic periodontitis. The invention also pertains to the development of process for preparation of effective composition with green tea extracts in the form of chips for local drug delivery system as an adjunct to scaling and root planing for treatment of chronic periodontitis. Periodontitis is an infection of the periodontium. Complex nature of the microbial biofilm in the subgingival environment requires thorough mechanical removal of plaque to improve periodontal health. Adjunctive chemotherapeutic agents along with non-surgical therapy enhance outcomes at sites not responsive to conventional treatment and achieve control of the disease. Green tea, apart from various health benefits has anti -inflammatory activity and is active against several perio-pathogens. The study is to assess the efficacy of locally delivered green tea extract as an adjunct to scaling and root planing in chronic periodontitis. 30 patients, both male and female with age range of 30- 55 years with probing depth 4-6 mm were selected. A split mouth design was followed. Treatment consisted of scaling and root planing and placement of green tea extract chips at the test site while no chip was placed at control site. Clinical parameters such as gingival index (GI), plaque index (PI), probing pocket depth and evaluation of the total microbial load (colony forming units / ml) were done at baseline and 21 days. Both the test and control groups showed statistically significant reduction in GI and PI, probing pocket depth after treatment (p<0.05). There was greater reduction in all the parame
