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Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors
专利权人:
Inc.;Enanta Pharmaceuticals
发明人:
Nakajima, Suanne,Sun, Ying,Tang, Datong,Xu, Gouyou,Porter, Brian,Or, Yat Sun,Wang, Zhe,Miao, Zhenwei
申请号:
AU2010200619
公开号:
AU2010200619B2
申请日:
2010.02.19
申请国别(地区):
AU
年份:
2013
代理人:
摘要:
#$%^&*AU2010200619B220131107.pdf#####Abstract The present invention relates to compounds of Formula (i) or (ii), or a pharmaceutically acceptable salt, ester, or 5 prodrug, thereof: formula (I), formula (II): which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and 10 are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCF infection. The invention also relates to methods of treating an HCV infection in a 15 subject by administering a pharmaceutical composition comprising the compounds of the present invention. C:NrPortbl GHMatters ROSG21 992211. DOC 19102110
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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