Zhenwei Miao,Ying Sun,Suanne Nakajima,Datong Tang,Frank Wu,Guoyou Xu,Yat Sun Or,Zhe Wang
申请号：
US12351144
公开号：
US08124584B2
申请日:
2009.01.09
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to compounds of Formula I, II or III, or a pharmaceutically acceptable salt, ester, or prodrug, thereof:wherein W is a substituted or unsubstituted heterocyclic ring system. The compounds inhibit serine protease activity, particularly the activity of hepatitis c virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis c virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
