Suanne Nakajima,Zhenwei Miao,Ying Sun,Datong Tang,Guoyou Xu,Brian Porter,Yat Sun Or,Zhe Wang
申请号:
US12505725
公开号:
US08236807B2
申请日:
2009.07.20
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The present invention relates to compounds of Formula I or II, or a pharmaceutically acceptable salt, ester, or prodrug, thereof:which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.