CHOO, Hyunah,KIM, Youngjae,SEONG, Jihye,NAM, Ghil Soo,CHO, Yong Seo
申请号：
EP17811428
公开号：
EP3560927A4
申请日:
2017.11.06
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
Azepine derivatives acting on 5-HT<；sub>；7<；/sub>；receptors and pharmaceutically acceptable salts thereof are disclosed. The azepine derivatives and the pharmaceutically acceptable salts thereof have high binding affinities for and high antagonistic activities on 5-HT<；sub>；7<；/sub>；receptors. Due to these advantages, the azepine derivatives and the pharmaceutically acceptable salts thereof can be applied to therapeutic or prophylactic agents for central nervous system diseases, such as depression, migraine, anxiety, pain, inflammatory pain, neuropathic pain, body temperature dysregulation, biorhythm dysregulation, sleep disturbance, and smooth muscle diseases where 5-HT<；sub>；7<；/sub>；receptors antagonistic activity is required.
