CATCHPOLE IAN RICHARD,GOUGH GERALD WAYNE,STEWARD MICHAEL,COOK FIONA,JESPERS ,LAURENT
申请号：
ZA201103588
公开号：
ZA201103588B
申请日:
2011.05.16
申请国别(地区):
ZA
年份:
2012
代理人:
摘要：
The invention relates to a method for selecting, isolating and/or recovering a peptide or polypeptide from a library or a repertoire of peptides and polypeptides ( e.g., a display system) that is resistant to degradation by a protease such as a protease found in the GI tract or pulmonary tissue of a human. Generally, the method comprises providing a library or repertoire of peptides or polypeptides, combining the library or repertoire with a protease under conditions suit able for protease activity, and selecting, isolating and/or recovering a peptide or polypeptide that is resistant to degradation by the protease and has a desired biological activity. The selected peptides and polypeptides have utility as therapeutics, eg for treating disease or conditions of GI tract or pulmonary tissue in humans.
