Methods for selecting protease resistant polypeptides

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专利权人:

グラクソ グループ リミテッド

发明人:

キャロライン、エネバー,ローラン、ジェスペル,マルゴルザタ、プペカ,イアン、エム、トムリンソン

申请号：

JP2011539034

公开号：

JP5840498B2

申请日:

2009.12.04

申请国别(地区):

JP

年份:

2016

代理人:

摘要：

The disclosure relates to a method for selecting, isolating and/or recovering a peptide or polypeptide from a library or a repertoire of peptides and polypeptides (e.g., a display system) that is resistant to degradation by a protease such as a protease found in the serum. Generally, the method comprises providing a library or repertoire of peptides or polypeptides, incubating the library or repertoire with a protease under conditions suitable for protease activity, and selecting, isolating and/or recovering a peptide or polypeptide that is resistant to degradation by the protease and has a desired biological activity. The selected peptides and polypeptides have utility as therapeutics, e.g., for treating disease in humans.

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