Derya UNUTMAZ;Francis ALONZO, III;Victor J. TORRES
发明人:
Victor J. TORRES,Derya UNUTMAZ,Francis ALONZO, III
申请号:
US13527438
公开号:
US20130039885A1
申请日:
2012.06.19
申请国别(地区):
US
年份:
2013
代理人:
摘要:
The present invention relates to methods for preventing or treating Human Immunodeficiency Virus (HIV) infection, inflammatory conditions, and graft-versus-host-disease (GVHD) in a subject. Therapeutic compositions of the present invention comprise Leukocidin E (LukE) and/or D proteins or polypeptides. The invention further relates to methods of treating Staphylococcus aureus infection by administering a composition comprising a CCR5 antagonist or any molecule that blocks LukE/D interaction with CCR5+ cells in an amount effective to treat the S. aureus infection in the subject.