An oral care appliance and a method of use are disclosed. The oral care appliance includes a mouthpiece with one or more enclosed compartments between an outer surface and an inner surface of the mouthpiece. The inner surface comprises at least one flexible membrane surrounding the one or more enclosed compartments. The oral care appliance also includes a control unit configured to regulate pressure variations in the one or more enclosed compartments to deform the flexible membrane and thereby perform an oral care action.