治療A型血友病的方法农业专利-农业学术服务平台

发明人:: SETH CHHABRA, EKTA,赛斯恰布拉　艾可塔,賽斯恰布拉　艾可塔,INNES, ALISON,英诺斯　艾利森,英諾斯　艾利森,RUDIN, DAN,鲁丁　丹,魯丁　丹,RICE, KARA,赖斯　卡拉,賴斯　卡拉,WONG, NANCY,冯　友菊,馮　友菊,KATRAGADDA, SURESH,卡察嘎达　苏雷,卡察嘎達　蘇雷

摘要：: The present disclosure provides a method of treating hemophilia A in a human subject in need thereof comprising administering to the subject a chimeric polypeptide comprising (i) a factor VIII (FVIII) protein and (ii) a von Willebrand factor (VWF) fragment comprising a D' domain of VWF and a D3 domain of VWF at a dosing interval.本公開提供一種治療有需要的人類個體的A型血友病的方法，該方法包括以給藥間隔向該個體施用嵌合多肽，該嵌合多肽包含(i)因子VIII(FVIII)蛋白，和(ii)包含VWF的D'域和VWF的D3域之馮威里氏因子(von Willebrand factor，VWF)片段。