Chimeric factor viii polypeptides and uses thereof

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专利权人:

BIOGEN MA INC.

发明人:

PETERS ROBERT,JIANG HAIYAN,CHHABRA EKTA SETH,LIU TONGYAO

申请号：

NZ62694513

公开号：

NZ626945A

申请日:

2013.01.12

申请国别(地区):

NZ

年份:

2016

代理人:

摘要：

Disclosed is a chimeric protein comprising a factor VIII protein and the D&rsquo； domain and D3 domain of Von Willebrand Factor, wherein the FVIII protein and VWF fragment are on separate polypeptide chains and are covalently linked. The VWF fragment is capable of preventing endogenous VWF from binding to the FVIII protein. Compositions and methods of treating bleeding diseases are also disclosed.

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