The present application provides an oral preparation which comprises N-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]-(2R,3R)-2,3-tetramethylene-butyl]-(1'R,2'S,3'R,4'S)-2,3-bicyclo[2,2,1]heptanedicarboxyimide hydrochloride (lurasidone) of the formula (1):a pregelatinized starch, a water-soluble excipient, a water-soluble polymer binder and a disintegrant；wherein a content of lurasidone in the preparation is 20 to 45% (wt/wt), and the pregelatinized starch is incorporated in an amount of 10 to 50% (wt/wt) based on the weight of the preparation； andwherein the disintegrant is one or more disintegrants selected from the group consisting of corn starch, crystalline cellulose, low substituted hydroxypropylcellulose, carmellose, carmellose ca lcium, carmellose sodium, croscarmellose sodium, carboxymethyl starch sodium and crospovidone.
