A heat exchange structure for support surface includes a mattress portion consisting of air cells disposed side-by-side, a mattress cover, a heat dissipation air cushion disposed between the mattress portion and the mattress cover, an air charging line, and an air supply unit connected to the heat dissipation air cushion via the air charging line. The heat dissipation air cushion has air holes formed on its top surface. When air is supplied from the air supply unit into the heat dissipation air cushion, an air chamber in the heat dissipation air cushion is expanded to create an air-flowing space between the mattress portion and the mattress cover. The air supplied into the air chamber continuously escapes from the heat dissipation air cushion into the air-flowing space to form air streams, which flow through and finally out of the air-flowing space while carrying heat and moisture away from the mattress cover.
