John M. Yanni,Jon E. Chatterton,Diane Michelle Senchyna,Daniel A. Gamache,Steven T. Miller
申请号：
US14244623
公开号：
US09447419B2
申请日:
2014.04.03
申请国别(地区):
US
年份:
2016
代理人:
摘要：
RNA interference is provided for inhibition of tumor necrosis factor α (TNFα) by silencing TNFα cell surface receptor TNF receptor-1 (TNFR1) mRNA expression, or by silencing TNFα converting enzyme (TACE/ADAM17) mRNA expression. Silencing such TNFα targets, in particular, is useful for treating patients having a TNFα-related condition or at risk of developing a TNFα-related condition such as the ocular conditions dry eye, allergic conjunctivitis, or ocular inflammation, or such as dermatitis, rhinitis, or asthma, for example.
