Senchyna, Diane Michelle,Gamache, Daniel A.,Chatterton, Jon E.,Miller, Steven T.,Yanni, John M.
申请号：
AU2007253776
公开号：
AU2007253776B2
申请日:
2007.05.17
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
RNA interference is provided for inhibition of tumor necrosis factor α(TNFα) by silencing TNFα cell surface receptor TNF receptor-1(TNFR1) mRNA expression, or by silencing TNFα converting enzyme (TACE/ADAM17)mRNA expression. Silencing such TNFα targets, in particular, is usefulfor treating patients having a TNFα-related condition or at risk of developinga TNFα-related condition such as the ocular conditions dry eye, allergicconjunctivitis, or ocular inflammation, or such as dermatitis, rhinitis, orasthma, for example.
