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DERIVE D'INDOLE, ET SEL DE QUALITE PHARMACOLOGIQUE DE CELUI-CI
专利权人:
KISSEI PHARMACEUTICAL CO., LTD.;KYORIN PHARMACEUTICAL CO., LTD.
发明人:
TATANI, KAZUYA,KONDO, ATSUSHI,KONDO, TATSUHIRO,KAWAMURA, NAOHIRO,SETO, SHIGEKI,KOHNO, YASUSHI
申请号:
CA2825134
公开号:
CA2825134A1
申请日:
2012.01.24
申请国别(地区):
CA
年份:
2012
代理人:
摘要:
The present invention provides: a compound (I) (in the formula: A is a pyridine ring, a furan ring, or the like; Y1 is an alkylene group having 1-6 carbon atoms; Y2 is a single bond or the like; R1 is -C(=O)-NH-SO2-R6, an acidic 5-membered heterocyclic group, or the like; R2 is a phenyl group that may have a substituent group, an aromatic heterocycle 5-membered ring that may have a substituent group, or the like; R3 is a halogen atom, an alkoxy group having 1-6 carbon atoms, or the like; R4 is a hydrogen atom, a halogen atom, or the like; R5 is a hydrogen atom or the like; and R6 represents an alkyl group having 1-6 carbon atoms, or the like) having EP1 receptor antagonism, and a pharmacologically acceptable salt thereof. Furthermore, the compound (I) can be used as a therapeutic drug or preventative drug for various symptoms of LUTS, particularly OABs.
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