РОДЕС СОЛАНЕС Роса (ES),ГАРСИЯ ДОМИНГЕС Нефтали (ES),ЛОПЕС ОРТЕГА Беатрис (ES),АЛЬВАРЕС ДЕ МОН СОТО Мельчор (ES),ДЕ ЛА ЭРА МАРТИНЕС Антонио (ES),МУНЬОС МУНЬОС Ан (ES),ЛЕДО ГОМЕС Франсиско (ES)
申请号：
RU2013128602/04
公开号：
RU2013128602A
申请日:
2011.11.22
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. The compound of formula (I) or its salt, prodrug or solvate: where Ph is phenyl； n is 2, 3 or 4； R is selected from the group consisting of hydrogen and C 1-6 alkyl； R is a radical of the formula - [[CH (R) ] -R], where m is 1； R, where provided, is selected from the group consisting of hydrogen, phenyl and C-C1-6 alkyl； R is selected from the group consisting of radicals: unsubstituted heteroaryl, substituted heteroaryl and substituted aryl, wherein these substituents are selected from a group consisting of C 1-6 alkyl, C 1-6 arylalkyl, phenyl, 5- or 6-membered heteroaryl, F, Cl, Br, I, trifluoromethyl, cyano, —N (R) (R), —OR, —SR, or —C ( O) R； where R, R, R, R and R are independently selected from a hydrogen atom, C 1-6 alkyl, phenyl and trifluoromethyl； or if R and / or R are different from a hydrogen atom, then R may also mean unsubstituted phenyl； or R and R, together with the nitrogen atom to which they are attached, form a substituted or unsubstituted heteroaryl group in which the indicated substituents are as defined above, provided that: 2 - [(4,4-diphenylbut-3-enylamino) methyl] phenol 3 - [(4,4-diphenylbut-3-enylamino) methyl] phenol, 5 - [(4,4-diphenylbut-3-enylamino) methyl] -2-methoxyphenol, 4 - [(4,4-diphenylbut -3-enylamino) methyl] -2,6-difluorophenol, benzyl- (5,5-diphenylpent-4-enyl) ethylamine, 6-chloro-9- (4,4-diphenylbut-3-enyl) -9H-purine , 9- (4,4-diphenylbut-3-enyl) -9H-purin-6-ylamine, and 5- (4,4-diphenylbut-3-enyl) -4,5,6,7-tetrahydroisoxazolo [4,5 -c] pyridin-3-o l are not included in formula (I) .2. The compound according to claim 1, where each of these substituents is selected from the group consisting of C 1-6 alkyl, C 1-6 arylalkyl, phenyl, 5- or 6-membered heteroaryl, F, Br, I, trifluoromethyl, cyano, —N (R) ( R), —OR, —SR or —C (O) R； where R, R, R and R are independently selected from a hydrogen atom, C-C1-6 alkyl, phenyl and trifluoromethyl, and R is selected from the group consisting of C-C1-6 alkyl, phenyl and trifluorometh
