Janssen Richard Antonius Jozef,Lekkerkerker Annemarie Nicolete,Aarbiou Jamil,Ouwehand Krista
申请号：
US201414775828
公开号：
US9952202(B2)
申请日:
2014.03.07
申请国别(地区):
美国
年份:
2018
代理人:
Klauber & Jackson LLP
摘要：
The present invention relates to methods and assays for identifying agents useful in the treatment of fibrotic diseases, in particular diseases related to fibroblast migration and differentiation. The invention provides polypeptide and nucleic acid TARGETs, siRNA sequences based on these TARGETs and antibodies against the TARGETs. The invention is further related to pharmaceutical composition comprising siRNA sequences based on the TARGETs and antibodies against the TARGETs for use in the treatment of fibrotic disease. The invention further provides in vitro methods for inhibition of fibroblast migration and differentiation.
