MANZO, Angelo Maria,CERIANI, Daniela,MAILLAND, Federico,SINGH, Saumya,ANDRES, Patricia,MCQUEEN, Lisa
申请号：
EPEP2016/050439
公开号：
WO2016/113242A1
申请日:
2016.01.12
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
The present invention relates to di-pidotimod benzathine. In particular, it relates to di-pidotimod benzathine in solid form such as in crystalline or amorphous； specific polymorphs are also disclosed such as Form M. Form H and hydrate Form H of di-pidotimod benzathine, in an additional aspect of the invention, solvates and cocrystals of hydrate Form H di-pidotimod benzathine are provided. In a further aspect of the invention, variable isopropanol solvates: variable ethanol solvates； variable hydrates； and a particular anhydrate are provided. Particular solid forms include variable isopropanol solvates Form J and Form O of di-pidotimod benzathine； variable ethanol solvates Form S and Form W of di-pidotimod benzathine； variable hydrate Form X of di-pidotimod benzathine； and anhydrate Form T of di-pidolimod benzathine. in further aspects of the invention, processes for making such solid forms are provided. In additional aspects of the invention, methods of treating infections or inflammatory diseases using one or more of such solid forms are provided.La présente invention concerne la di-pidotimod benzathine. En particulier, l'invention concerne la di-pidotimod benzathine sous forme solide telle que cristalline ou amorphe ； l'invention concerne également des polymorphes spécifiques comme la forme M. L'invention concerne dans un autre aspect de l'invention la forme H et la forme hydrate H de la di-pidotimod benzathine, des solvates et des co-cristaux de la forme hydrate H de la di-pidotimod benzathine. Un autre aspect de l'invention concerne des solvates d'isopropanol variables : des solvates d'éthanol variables ； des hydrates variables ； et un anhydrate particulier. Des formes solides particulières comprennent les solvates d'isopropanol variables Forme J et Forme O de la di-pidotimod benzathine ； les solvates d'éthanol variables Forme S et Forme W de la di-pidotimod benezathine ； l'hydrate variable Forme X de la di-pidotimod benzathine ； et l'anhydrate Forme T de la di
