HADIDA RUAH, SARA,HAMILTON, MATTHEW,MILLER, MARK,GROOTENHUIS, PETER D. J.,BEAR, BRIAN,MCCARTNEY, JASON,ZHOU, JINGLAN
申请号：
CA2627358
公开号：
CA2627358C
申请日:
2006.11.08
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
Compounds of the present invention, and pharmaceutically acceptablecompositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC")transportersor fragments thereof, including Cystic Fibrosis Transmembrane ConductanceRegulator("CFTR"). In one broad aspect, there is disclosed a compound of the generalformula (I):(see formula I)or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R'3, R4,and n are describedherein. In a more specific embodiment, the invention relates to a compoundhaving thefollowing formula:(see formula II).
