LOOKER, ADAM R.,LITTLER, BENJAMIN JOSEPH,CHOUDHURY, ANUSUYA,HARRISON, CRISTIAN L.,VELURI, RAVIKANTH,RYAN, MICHAEL P.,JIANG, LICONG,LUSS-LUSIS, EDUARD
申请号：
CA2852991
公开号：
CA2852991C
申请日:
2012.11.08
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
Compounds of the present invention, are presented by the following formula:or a pharmaceutically acceptable salt thereof, wherein R, R1, R2, R3, Y and R4are as describedherein, and pharmaceutically acceptable compositions thereof, are useful asmodulators ofATP-Binding Cassette ("ABC") transporters or fragments thereof, includingCystic FibrosisTransmembrane Conductance Regulator ("CFTR"). The present invention alsorelates tomethods of treating ABC transporter mediated diseases using compounds of thepresentinvention.
