PROBLEM TO BE SOLVED: To provide a method for producing a naftopidil preparation stable against discoloration by light.SOLUTION: There is provided a method for producing a pharmaceutical preparation containing naftopidil as an active ingredient and pharmaceutical additives and being in a form of compacted intraorally disintegrable tablet which does not undergo light discoloration caused by the copresence of naftopidil and lactose, which method comprises the steps of preparing granules comprising a pharmaceutical additive selected from the group consisting of saccharose, glucose, etc., and naftopidil and producing tablets having a tablet hardness of 1 kg or larger from the granules.COPYRIGHT: (C)2011,JPO&INPIT【課題】光による変色のない安定なナフトピジル製剤の製造方法を提供する。【解決手段】有効成分としてナフトピジルと製剤用添加物とを含みナフトピジルと乳糖との共存を原因とする光による着色を生じない圧縮型口腔内崩壊錠剤の形態の医薬組成物の製造方法であって、白糖、ブドウ糖などからなる群から選ばれる製剤用添加物とナフトピジルとからなる造粒物を調製した後、錠剤硬度が1Kg以上の錠剤を製造する工程を含む方法。【選択図】なし
