Method and composition for providing enhanced oral and systemic health care benefits and method and composition for regulating up or down regulating the metabolic of periodontal disease.
HARSH M. TRIVEDI,DAVIDE MIKSA,CORTNEY WORRELL,CHANDAS MACIAS,TAO XU,YING YANG,YANAN HU
申请号：
BRPI0924915
公开号：
BRPI0924915A2
申请日:
2009.04.01
申请国别(地区):
BR
年份:
2015
代理人:
摘要：
The present invention discloses novel uses of specific menthol-derivative compounds of Formula 1, and compositions thereof, for methods of providing oral and systemic health care benefits, and methods of up-regulating or down-regulating periodontal disease metabolites: Formula 1 wherein, X is an oxygen atom or an NH radical； and R is an unsubstituted or substituted aryl or aliphatic radical. In some embodiments, the oral and systemic health care benefits include biofilm anti-attachment, anti-inflammation, anti-oxidant, anti-bone loss, and anti-microbial benefits. In some embodiments, the periodontal disease metabolites correspond to healthy and/or diseased oral status and allow differential diagnosis of oral health.
