This provides octilamida derived Bicyclo [3,2,1] or one of its pharmaceutically acceptable salts, and Pharmaceutical compositions and Methods of use. The compounds are useful in the treatment of neurodegenerative disorders of the CNS: (Cognitive, psychiatric or Neurological).Claim 1: a compound having the formula (1), where l is - nhco - or - with -； and R1 and R2 are each, independently, alkyl, cycloalkyl, aryl or heteroaryl cetocicloalquilo, heterociclilo, which is optionally mono -, di - or trisustituido, Independent with alqui So, alkoxy, halogen, Nitro, cyano, amino, trifluoroalquilo, alquilamino dialquilamino aryl acyl,,,,Heteroaryl, heterociclilo, heterociclil - - nhr3, R3, R3 (alkyl) - n, - C (o) nhr3, - C (o) n (alkyl) - NHC (or R3, R3), N - (alkyl) C (o) - o or - OR3 R3, R3, where: is alkyl or cycloalkyl C1 C1 - 6 - 6, which is optionally substituted by Halogen, - CN, - NH2, - NH (c1-3 alkyl (alkyl) - n, c1-3 alkyl) - 2, 3 - C1 Terociclilo, c1-3 alkyl carbamate -, - C (o) NH (c1-3 alkyl, - C (o) n (c1-3 alkyl) 2- NHC (or c1-3 alkyl) - N - (alkyl c1-3) - C (o) - c1-3 alkyl or alkyl, oh - or - C1 - 6； or one of its pharmaceutically acceptable Salts.La presente proporciona derivados de biciclo[3,2,1]octilamida o una de sus sales farmacéuticamente aceptables； y composiciones farmacéuticas y sus métodos de uso. Los compuestos son útiles en el tratamiento de trastornos del SNC: cognitivos, neurodegenerativos (psiquiátricos o neurológicos).Reivindicación 1: Un compuesto que tiene la fórmula (1), en donde: L es -NHCO- o -CONH-； y R1 y R2 son cada uno, de modo independiente, alquilo, cicloalquilo, cetocicloalquilo, heterociclilo, arilo o heteroarilo, que está opcionalmente mono-, di- o trisustituido, de modo independiente, con alquilo, alcoxi, halógeno, ciano, nitro, trifluoroalquilo, amino, alquilamino, dialquilamino, acilo, arilo, heteroarilo, heterociclilo, heterociclil-R3, -NHR3, -N(alquil)R3, -C(O)NHR3, -C(O)N(alquil)R3, -NHC(O)R3, -N(alquil)C(O)R3, -OH u -OR3
