HOFFMANN MATTHIAS,BISCHOFF DANIEL,DAHMANN GEORG,KLICIC JASNA,SCHAENZLE GERHARD,WOLLIN STEFAN LUDWIG MICHAEL,CONVERS-REIGNIER SERGE GASTON,EAST STEPHEN PETER,MARLIN FREDERIC JACQUES,MCCARTHY CLIVE,SCOT
申请号：
NZ61919712
公开号：
NZ619197A
申请日:
2012.07.19
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
Disclosed herein are 5-oxygen substituted quinolines of formula (1) wherein R1 is a linear or branched C1-6-alkyl, wherein R1 is substituted by R3 which is selected from the group consisting of a three-, four-, five-, six- or seven-membered cycloalkyl a five-, six- or seven-membered, saturated heterocycle comprising one, two or three heteroatoms each independently selected from the group consisting of N, S and O and a five- or six-membered heteroaryl comprising one, two or three heteroatoms each independently selected from the group consisting of N, S and O and the other substituents are as defined herein. Also disclosed is the use of the compounds in the preparation of medicaments for the treatment of diseases such as asthma, COPD, allergic rhinitis, allergic dermatitis and rheumatoid arthritis.
