MILNE, Jill C.,JIROUSEK, Michael R.,BEMIS, Jean E.,VU, Chi B.,MILNE JILL C,MILNE, JILL C.,JIROUSEK MICHAEL R,JIROUSEK, MICHAEL R.,BEMIS JEAN E,BEMIS, JEAN E.,VU CHI B,VU, CHI B.
申请号：
ES10814349
公开号：
ES2599626T3
申请日:
2010.08.31
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of Formula I: ** Formula ** or a pharmaceutically acceptable salt, hydrate, solvate, enantiomer or stereoisomer thereof； wherein R1, R2 and R3 are each independently selected from the group consisting of -H, -D, -Cl, -F, -CN, -NH2, -NH (C1-C3 alkyl), -N (C1 alkyl -C3) 2, -NH (C (O) C1-C3 alkyl), -N (C (O) C1-C3 alkyl) 2, -C (O) H, -C (O) C1-C3 alkyl, - C (O) O-C1-C3 alkyl, -C (O) NH2, -C (O) NH (C1-C3 alkyl), -C (O) N (C1-C3 alkyl) 2, -C1-C3 alkyl , -O-C1-C3 alkyl, -S (O) C1-C3 alkyl and -S (O) 2-C1-C3 alkyl； W1 and W2 are each independently -NH, S, NR, or W1 and W2 can be taken together to form an imidazolidine or piperazine group； each a, b, c and d is independently -H, -D, -CH3, -OCH3, -OCH2CH3, -C (O) OR or -OZ or benzyl, or two of a, b, cyd can be taken together, together with the only carbon atom to which they are attached, to form a cycloalkyl - optionally substituted with halogen, C1-C3 alkyl, hydroxyl, alkoxy and / or cyano - or a heterocycle； each n, o, p and q is independently 0 or 1； each L is independently -O-, -S-, -S (O) -, -S (O) 2-, -SS-, ** Formula ** or ** Formula ** each g is independently 2, 3 or 4； each h is, independently, 1, 2, 3 or 4； m is 0, 1, 2 or 3； each R6 is independently H or C1-C6 alkyl, or both R6 groups, when taken together with the nitrogen to which they are attached, can form a heterocycle； each R7 is independently e, H or linear or branched C1-C10 alkyl which may be optionally substituted with OH, NH2, CO2R, CONH2, phenyl, C6H4OH, imidazole or arginine； each e is independently H or any one of the side chains of a naturally occurring amino acid； each Z is independently -H or ** Formula ** with the proviso that there is at least one ** Formula ** in the compound； each r is independently 2, 3 or 7； each s is independently 3, 5 or 6； each t is independently 0 or 1； each v is independently 1, 2 or 6； R4 and R5 are each independently hydrogen, deuterium, -C1-C4 alkyl, -halogen, -OH, -C (O) C1-C4 alkyl, -O-aryl, -O-benzyl, -
