Even when being released in a region from a lower small intestineto a large intestine with various coatings, bisacodyl is inadequatelyeffective because of its hardness to dissolve due to its poor solubility,and thus a more drug should be contained. In the related art, therehave been no techniques for allowing bisacodyl and dioctyl sodiumsulfosuccinate to be simultaneously released in a region from a lowersmall intestine to a large intestine.A solid formulation having a core particle containing bisacodyland dioctyl sodium sulfosuccinate coated with an enteric coating whichallows the drugs to be released in a region from a lower small intestineto a large intestine can be used as an excellent pharmaceutical product .
