Krizman, David B.,Hembrough, Todd,Thyparambil, Sheeno
申请号:
AU2011352231
公开号:
AU2011352231B2
申请日:
2011.12.27
申请国别(地区):
AU
年份:
2016
代理人:
摘要:
Specific peptides are provided, and derived ionization characteristics of those peptides, from the Hepatocyte Growth Factor Receptor (cMET) protein. The peptides are advantageous for quantifying, by the method of Selected Reaction Monitoring (SRM) mass spectrometry, the cMET protein directly in biological samples that have been fixed in formalin, or what can also be termed as Multiple Reaction Monitoring (MRM) mass spectrometry. Such biological samples are chemically preserved and fixed where the biological sample is selected from tissues and cells treated with formaldehyde containing agents/fixatives including: formalin-fixed tissue/cells; formalinfixed/ paraffin embedded (FFPE) tissue/cells; FFPE tissue blocks and cells from those blocks; and tissue culture cells that have been formalin fixed and or paraffin embedded.