Controlled HNO release through intramolecular cyclization-elimination

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专利权人:

The Johns Hopkins University

发明人:

John P. Toscano,Art D. Sutton

申请号：

US14439800

公开号：

US09676708B2

申请日:

2013.10.30

申请国别(地区):

US

年份:

2017

代理人:

摘要：

Protected HNO donors designed to undergo non-enzymatic release at neutral pH via an intramolecular cyclization-elimination are disclosed. The rate of cyclization, and therefore HNO release, can be controlled by substituents and chain length. Thus, biologically useful HNO donors having tunable HNO release rates are provided.

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