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Long-release oral bioadhesive tablets
专利权人:
コロンビア・ラボラトリーズ・(バミューダ)・リミテッド;コロンビア・ラボラトリーズ・(バミューダ)・リミテッド
发明人:
ウィリアム・ジェイ・ボローニャ,ハワード・エル・レビーン,フィリップ・カルティエ,ドミニーク・ドゥ・ジーグラー
申请号:
JP2000565858
公开号:
JP5411398B2
申请日:
1999.08.24
申请国别(地区):
JP
年份:
2014
代理人:
摘要:
A bioadhesive tablet wherein the active ingredient may be protected from water or the surrounding environment, thereby protecting it from metabolism or from other degradation caused by moisture, enzymes, or pH effects, and making it bioavailable only at a controlled rate. The active ingredient may be protected from moisture during the manufacturing process and more importantly may be protected from moisture and the immediate septic environment until after the patient has applied the tablet, and then only at a slow and controlled rate. It is by this process of progressive hydration that the active ingredient remains protected for many hours after administration. It is also by the process of progressive hydration that controlled and sustained release is achieved because only that part of the active ingredient that is the hydrated (aqueous) fraction of the tablet is available for absorption (bioavailable).
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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