Alastair Morgan Mackay;Mark F. Pittenger;Stephen L. Gordon
发明人:
Mark F. Pittenger,Stephen L. Gordon,Alastair Morgan Mackay
申请号：
US13540021
公开号：
US08852575B2
申请日:
2012.07.02
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Disclosed are compositions and methods for method of treating a subject having reduced cardiac function or cardiac disease by administering adult bone marrow-derived stem cells to an individual. In some embodiments, the subject is a myocardial infarction patient or congestive heart failure patient. These cells can be administered as a liquid injectable or as a preparation of cells in a matrix which is or becomes solid or semi-solid. The cells can be genetically modified to enhance myocardial differentiation and integration. Also disclosed is a method for replacing cells ex vivo in a heart valve for implantation.
